Antigen processing: HLA-DO – a hitchhiking inhibitor of HLA-DM
نویسنده
چکیده
Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, expressed in only a subset of antigen-presenting cells, binds HLA-DM and blocks HLA-DM-catalyzed peptide loading of class II molecules.
منابع مشابه
Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO.
CD4(+) T cells play a central role in adaptive immunity. The acknowledgment of their cytolytic effector function and the finding that endogenous antigens can enter the HLA class II processing pathway make CD4(+) T cells promising tools for immunotherapy. Expression of HLA class II and endogenous antigen, however, does not always correlate with T-cell recognition. We therefore investigated proce...
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عنوان ژورنال:
- Current Biology
دوره 8 شماره
صفحات -
تاریخ انتشار 1998